Sickle cell anemia dating
Many of these are, however, covered fairly comprehensively in blog entries.
These include progress in stem cell research, many topics of epigenetics, several key gene-activation pathways, mitochondrial dynamics, redox related pathways, telomere-related pathways, health-producing properties of plant polyphenols, stress-responses and hormesis, quorum sensing in biofilms, microtubules, bacterial communications, nano delivery of therapeutic substances, quantum biology, systems biology, human bacterial biomes, roles of RNA species, age-related diseases including Alzheimers, Parkinsons, diabetes and cancers, evolutionary origins of our signaling systems, exosomal communication systems, cell senescence, signaling gasses, interspecies communications, circadian regulation and progress towards creating a Grand Unified Theory of biology and aging - to mention just a few.
Some like lipofuscin accumulation, telomere shortening and tissue glycation and even cancers and heart diseases are definitely downstream in the causal chain.
I expect to be forwarding the development of that GUT in close cooperation with Jim Watson, and at some point this will become the subject of a new book.
I will eventually rewrite this treatise from a different perspective.
Meanwhile, if you would like to understand how my thinking has evolved in the last five years, you can check out my May 2014 blog entry FIVE-YEAR PROGRESS REPORT ON MAJOR TRENDS IMPACTING ON LONGEVITY.
A comprehensive document for the benefit of people interested in living very long healthy lives and who are willing to adapt emerging knowledge personally to do so.  FORWARD VIEW FROM JULY 2014 More than six years have elapsed from drafting the initial version of this treatise and despite many updates parts of it show age.
Some of the theories are more basic and upstream of the others.
Also I need mention Melody Winnig, a researcher-writer who performs important daily research literature surveillance for me and Jim.
As time progressed, the process of updating this treatise has became increasingly daunting, in part because its organization no longer reflects how I now think about longevity or longevity-related interventions.
It seems that for everything I learn, I discover there are at least two new things yet to be learned.
At first, few people read the blog, but over the years its readership as well as the attention it has received from the scientific community have been increasing exponentially.
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And, to know how to do that based on new scientific discoveries, it was necessary to consider vast, disparate and detailed bodies of scientific knowledge.